Pyruvate carboxylase (PC) Rabbit mAb

Catalog Number:

77190

Amount:

100μg

Price:

$318

Swiss-Prot No:

P11498

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human Pyruvate carboxylase (PC)

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF