DDB2 Rabbit mAb

Catalog Number:

77165

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q92466

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human DDB2

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF