NCF4/p40-phox Rabbit mAb

Catalog Number:

77131

Amount:

100μg

Price:

$318

Swiss-Prot No:

Q15080

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human NCF4/p40-phox.

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IHC,IP

Background:

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

References:

appl_detail:

WB 1:500 - 1:2000
IHC 1:50 - 1:200
IP 1:50 - 1:200

Datasheet PDF