Insulin-degrading enzyme (IDE) Rabbit mAb

Catalog Number:

77104

Amount:

100μg

Price:

$318

Swiss-Prot No:

P14735

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptInsulin-degrading enzyme (Insulin-degrading enzyme (IDE)) derived from human Insulin-degrading enzyme (Insulin-degrading enzyme (IDE))

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF