GLS K311 succinylation antibody

Catalog Number:

58007

Amount:

100μg

Price:

$390

Swiss-Prot No:

O94925

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl,0.02% sodium azide and 50% glycerol.

Storage/Stability:

Store at -20℃/1 year

Immunogen:

The antiserum was produced against synthesized Peptide sequence around succinylation site of lysine 311 derived from Human GLS.

Purification:

The antibody was produced by immunizing rabbits with synthetic succinylated peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific succinylated peptide. Non-succinyl specific antibodies were removed by chromatogramphy using non-succinylpeptide.

Specificity/Sensitivity:

Applications:

WB,IHC

Background:

GLS is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Lysine 311 of GLS could be succinylated under oxidative stress, thus promoting GLS tetramer formation and activity (Tong et al. Mol Cell. 2021).

References:

appl_detail:

Datasheet PDF