SUCLA2(Phospho-Ser79) Antibody

Catalog Number:

58009

Amount:

100μg

Price:

$390

Swiss-Prot No:

Q9P2R7

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl,0.02% sodium azide and 50% glycerol.

Storage/Stability:

Store at -20℃/1 year

Immunogen:

The antiserum was produced against synthesized Peptide sequence around phosphorylation site of serine 79 derived from Human SUCLA2.

Purification:

The antibody was produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Specificity/Sensitivity:

Applications:

WB,IHC

Background:

Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. Serine 79 of SUCLA2 could be phosphorylated by p38 upon oxidative stress (Tong et al. Mol Cell. 2021).

References:

appl_detail:

Datasheet PDF