KMT5A/SETD8/Pr-SET7 Antibody

Catalog Number:	49648
other_names:	H4 K20 HMTase antibody H4 K20 specific histone methyltransferase antibody H4-K20-HMTase SETD8 antibody Histone H4 K20 methyltransferase antibody Histone lysine N methyltransferase H4 lysine 20 specific antibody
Amount:	100μg
calculated_mw:
host_species:	Rabbit
Price:	$319
Swiss-Prot No:	Swiss-Prot#:Q9NQR1
Form of Antibody:	1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage/Stability:
Immunogen:	Recombinant protein
Purification:	ProA affinity purified
Specificity/Sensitivity:
Applications:	WB, FC
Background:	Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. All monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions , benef playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contribute to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53 / TP53 at 'Lys-382', leading to repress p53 / TP53-target genes.
References:
appl_detail:	WB: 1:500-1:2,000 FC: 1:50-1:100
	Datasheet PDF

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