FKBP12 Antibody

Catalog Number:	49468
other_names:	12 kDa FK506-binding protein antibody 12 kDa FKBP antibody Calstabin 1 antibody FK506 binding protein 1 antibody FK506 binding protein 12 antibody FK506 binding protein 1A (12kD) antibody FK506 binding protein 1A 12kDa antibo
Amount:	100μg
calculated_mw:	12 kDa
host_species:	Rabbit
Price:	$319
Swiss-Prot No:	Swiss-Prot#:P62942
Form of Antibody:	1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage/Stability:
Immunogen:	recombinant protein
Purification:	ProA affinity purified
Specificity/Sensitivity:
Applications:	WB, ICC/IF
Background:	Immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases which bind to and mediate the effects of immunosuppressive drugs such as Cyclosporin, FK506 and Rapamycin. FKBP12.6, also known as FK506-binding protein 1B, is a 108 amino acid immunophilin belonging to the FKBP-type PPIase family. Subcellularly localized to the cytoplasm, FKBP12.6 binds to RyR in cardiac muscle sarcoplasmic reticulum and possibly plays a unique physiological role in excitation-contraction coupling in cardiac muscle. FKBP12.6 also catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Ubiquitously expressed, FKBP12.6 is found at highest levels in brain and thymus. FKBP12.6 is expressed as two isoforms produced by alternative splicing.
References:
appl_detail:	WB: 1:500-1:1000 ICC: 1:100-1:500
	Datasheet PDF

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