Sodium Potassium ATPase Antibody

Catalog Number:

48913

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P05023

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

recombinant protein

Purification:

ProA affinity purified

Specificity/Sensitivity:

Applications:

WB, ICC/IF, IHC, FC

Background:

The ubiquitously expressed sodium/potassium-ATPase (Na⁺/K⁺-ATPase) exists as an oligomeric plasma membrane complex that couples the hydrolysis of one molecule of ATP to the importation of three Na⁺ ions and two K⁺ ions against their respective electrochemical gradients. As a member of the P-type family of ion motives, Na⁺/K⁺-ATPase plays a critical role in maintaining cellular volume, resting membrane potential and Na+-coupled solute transport. Multiple isoforms of three subunits, α, β and γ, comprise the Na⁺/K⁺-ATPase oligomer. The α subunit contains the binding sites for ATP and the cations; the glycosylated β subunit ensures correct folding and membrane insertion of the α subunits. The small γ subunit co-localizes with the α subunit in nephron segments, where it increases the affinity of Na⁺/K⁺-ATPase for ATP. The β subunit, but not the γ subunit, is essential for normal activity of Na⁺/K⁺-ATPase.

References:

appl_detail:

WB: 1:1,000-5,000
IHC: 1:50-1:200
ICC: 1:50-1:200

FC: 1:50-1:100

Datasheet PDF