p70 S6 Kinase beta Antibody

Catalog Number:

48568

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9UBS0

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

peptide

Purification:

Peptide affinity purified

Specificity/Sensitivity:

Applications:

WB, ICC, IHC, FC

Background:

p70 S6 kinase is a mitogen activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression. p70 S6 kinase phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. A second isoform, p85 S6 kinase, is derived from the same gene and is identical to p70 S6 kinase except for 23 extra residues at the amino terminus, which encode a nuclear localizing signal. Both isoforms lie on a mitogen activated signaling pathway downstream of phosphoinositide-3 kinase (PI-3K) and the target of rapamycin, FRAP/mTOR, a pathway distinct from the Ras/MAP kinase cascade. Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the RPS6KB2 gene. Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.

References:

appl_detail:

WB: 1:500
IHC: 1:200
ICC: 1:200

FC: 1:100-1:200

Datasheet PDF