MSH6 Antibody

Catalog Number:	48563
other_names:	DNA mismatch repair protein Msh6 antibody G/T mismatch binding protein antibody G/T mismatch-binding protein antibody GTBP antibody GTMBP antibody hMSH6 antibody HNPCC 5 antibody HNPCC5 antibody HSAP antibody M
Amount:	100μg
calculated_mw:	152 kDa
host_species:	Rabbit
Price:	$319
Swiss-Prot No:	Swiss-Prot#:P52701
Form of Antibody:	1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage/Stability:
Immunogen:	peptide
Purification:	Peptide affinity purified
Specificity/Sensitivity:
Applications:	WB, ICC, IHC, FC
Background:	The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between nonidentical DNA sequences, and induces both checkpoint and apoptotic responses following certain types of DNA damage. MSH6 heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. Mutations in MSH6 and other MMR proteins have been found in a large proportion of hereditary nonpolyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world.
References:
appl_detail:	WB: 1:1,000 IHC: 1:200 ICC: 1:200 FC: 1:100-1:200
	Datasheet PDF

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