ERG Antibody

Catalog Number:	48189
other_names:	Avian erythroblastosis virus E-26 (v-ets) oncogene related antibody D030036I24Rik antibody Erg 3 antibody Erg antibody ERG/EWS fusion gene, included antibody ERG/FUS fusion gene, included antibody ERG/TMPSSR2 fusion gene, inc
Amount:	100μg
calculated_mw:	55 kDa
host_species:	Rabbit
Price:	$319
Swiss-Prot No:	Swiss-Prot#:P11308
Form of Antibody:	1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage/Stability:
Immunogen:	peptide
Purification:	Peptide affinity purified
Specificity/Sensitivity:
Applications:	WB, ICC, IHC
Background:	Transcriptional regulator ERG is a nuclear protein that binds purine-rich sequences of DNA. Transcriptional regulator ERG is required for platelet adhesion to the subendothelium and regulates hematopoiesis. It has a DNA binding domain and a PNT (pointed) domain. ERG is expressed at higher levels in early myelocytes than in mature lymphocytes (types of white blood cells). Therefore ERG may act as a regulator of differentiation of early hematopoietic cells. This gene can be classified as a proto-oncogene, which participates in chromosomal translocations (a popular example of this phenomenon is the Philadelphia chromosome). Essentially during cell division ERG can accidentally get stuck onto a different chromosome than where it belongs.
References:
appl_detail:	WB: 1:500 ICC: 1:200
	Datasheet PDF

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