Smad2 (Phospho-S250) Antibody

Catalog Number:

13406

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q15796

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

Synthetic phospho-peptide corresponding to residues surrounding Ser250 of human Smad2.

Purification:

ProA affinity purified

Specificity/Sensitivity:

Applications:

WB, FC

Background:

Smad proteins, the mammalian homologs of the Drosophila mothers against decapentaplegic (Mad), have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1 (also designated Madr1 or JV4-1) and Smad5 are effectors of BMP-2 and BMP-4 function, while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFβ and Activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to Activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad proteins.

References:

appl_detail:

WB: 1:1,000-1:2,000



FC: 1:50-1:100

Datasheet PDF