MSK1(Phospho-phospho S376) Antibody

Catalog Number:

13389

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:O75582

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

Synthetic phospho-peptide corresponding to residues surrounding Ser376 of human MSK1.

Purification:

ProA affinity purified

Specificity/Sensitivity:

Applications:

WB, ICC, IHC, IP

Background:

The family of ribosomal S6 kinases (Rsks), designated Rsk-1, Rsk-2 and Rsk-3, have been implicated as important signaling intermediates in response to a broad range of ligand-activated receptor tyrosine kinases. A unique feature common to the three members of the Rsk family is that each possesses two non-identical complete kinase catalytic domains. A related S6 kinase, p70 S6 kinase, functions to phosphorylate the S6 protein on ribosomal 40S subunits. p70 S6 kinase b shares high sequence homology with p70 S6 kinase, except in the carboxy terminus where it contains a proline-rich domain that may be involved in SH3 domain containing protein interactions. MSK1 (also designated RLPK) is related to Rsk and p70 S6 kinase family members and is thought to be structurally similar to Rsk family members, but it may be regulated by distinct mechanisms.

References:

appl_detail:

WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200

Datasheet PDF