Src(Phospho-Y419) Antibody

Catalog Number:

13367

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P12931

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

Synthetic phospho-peptide corresponding to residues surrounding Tyr419 of human Src.

Purification:

ProA affinity purified

Specificity/Sensitivity:

Applications:

WB, FC

Background:

The Src family of protein tyrosine kinases, which includes Src, Lyn, Fyn, Yes, Lck, Blk, and Hck, are important in the regulation of growth and differentiation of eukaryotic cells. Src activity is regulated by tyrosine phosphorylation at two sites, but with opposing effects. While phosphorylation at Tyr416 in the activation loop of the kinase domain upregulates enzyme activity, phosphorylation at Tyr527 in the carboxy-terminal tail by Csk renders the enzyme less active.

References:

appl_detail:

WB: 1:1,000



FC: 1:50-1:100

Datasheet PDF