KDM7A Antibody

Catalog Number:

47806

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q6ZMT4
NCBI Gene ID:80853
Gene Accssion:NP_085150

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human KDM7A

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total KDM7A protein.

Applications:

IHC

Background:

Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.

References:

appl_detail:

IHC dilution:1: 30-150

Datasheet PDF