RGR Antibody

Catalog Number:

47789

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P47804
NCBI Gene ID:5995
Gene Accssion:NP_001012738

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human RGR

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total RGR protein.

Applications:

WB, IHC

Background:

This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms.

References:

appl_detail:

WB dilution:1:500-2000
IHC dilution:1: 30-150

Datasheet PDF