RRP8 Antibody

Catalog Number:

47746

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:O43159
NCBI Gene ID:23378
Gene Accssion:BC001071

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human RRP8

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total RRP8 protein.

Applications:

WB, IHC

Background:

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+?ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

References:

appl_detail:

WB dilution:1:500-2000
IHC dilution:1: 50-300

Datasheet PDF