PHTF1 Antibody

Catalog Number:

47727

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9UMS5
NCBI Gene ID:10745
Gene Accssion:BC002447

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human PHTF1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total PHTF1 protein.

Applications:

IHC

Background:

PHTF1 (putative homeodomain transcription factor 1), also known as PHTF, is a potential transcription regulator. It is a ubiquitously expressed integral, multipass membrane protein with predominant expression in testis. PHTF1 is associated with the ER (endoplasmic reticulum) and contains one bHLH (basic helix-loop-helix) domain. It is present in the cell during meiosis and spermiogenesis but, by the end of spermiogenesis, is released from the mature cell within the residual bodies. This implies that PHTF1 may play a role in the spermatozoa maturation process. In addition, PHTF1 is believed to interact with FEM1B and may be responsible for recruiting FEM1B to the surface of the ER membrane. This suggests that PHTF1 acts as a sequestering or anchoring protein for FEM1B. Two PHTF1 isoforms exist due to alternate splicing events. Isoform 2 is the shorter form and lacks the amino acid residues 648 to 762.

References:

appl_detail:

IHC dilution:1: 20-100

Datasheet PDF