COX11 Antibody

Catalog Number:

47703

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9Y6N1
NCBI Gene ID:1353
Gene Accssion:BC005895

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human COX11

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total COX11 protein.

Applications:

WB, IHC

Background:

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6.?

References:

appl_detail:

WB dilution:1:1000-5000
IHC dilution:1: 25-100

Datasheet PDF