G6PC Antibody

Catalog Number:

47687

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P35575
NCBI Gene ID:2538
Gene Accssion:NP_000142

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human G6PC

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total G6PC protein.

Applications:

IHC

Background:

Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.

References:

appl_detail:

IHC dilution:1: 50-300

Datasheet PDF