IL4R Antibody

Catalog Number:

47653

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P24394
NCBI Gene ID:3566
Gene Accssion:NP_000409

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human IL4R

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total IL4R protein.

Applications:

IHC

Background:

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.

References:

appl_detail:

IHC dilution:1: 25-100

Datasheet PDF