IFI35 Antibody

Catalog Number:

47647

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P80217
NCBI Gene ID:3430
Gene Accssion:NP_001317159

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human IFI35

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total IFI35 protein.

Applications:

IHC

Background:

The Interferon family of proteins are able to alter the expression of a variety of target genes, thereby controlling various events within the cell. IFI-35 (Interferon-induced 35 kDa protein), also known as IFP35, is a 286 amino acid interferon-induced protein. Localized to the nucleus and expressed in macrophages, fibroblasts and epithelial cells, IFI-35 is a leucine zipper protein that can form homodimers, but, unlike most leucine zipper proteins, cannot bind DNA. Upon induction by IFN-, IFI-35 associates with Nmi (N-Myc-interacting protein), resulting in the formation of a high molecular weight complex that is thought to play a role in IFN- signaling and cellular responses. Once complexed with Nmi, IFI-35 is unable to be degraded by the proteasome, suggesting that IFI-35 is protected from degradation only when needed by IFN-. Two isoforms of IFI-35 exist due to alternative splicing events.

References:

appl_detail:

IHC dilution:1: 30-150

Datasheet PDF