RNF217 Antibody

Catalog Number:

47643

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q8TC41
NCBI Gene ID:154214
Gene Accssion:NP_001273327

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human RNF217

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total RNF217 protein.

Applications:

WB

Background:

This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants.

References:

appl_detail:

WB dilution:1:200-1000

Datasheet PDF