HLA-DPA1 Antibody

Catalog Number:

47630

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P20036
NCBI Gene ID:3113
Gene Accssion:NP_291032

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human HLA-DPA1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total HLA-DPA1 protein.

Applications:

WB, IHC

Background:

HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

References:

appl_detail:

WB dilution:1:500-2000
IHC dilution:1: 40-200

Datasheet PDF