ERI1 Antibody

Catalog Number:

47625

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q8IV48
NCBI Gene ID:90459
Gene Accssion:NP_699163

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human ERI1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total ERI1 protein.

Applications:

IHC

Background:

RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

References:

appl_detail:

IHC dilution:1: 20-100

Datasheet PDF