GLUD1 Antibody

Catalog Number:

47580

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P00367
NCBI Gene ID:2746
Gene Accssion:NP_005262

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human GLUD1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total GLUD1 protein.

Applications:

WB, IHC

Background:

This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.

References:

appl_detail:

WB dilution:1:500-2000
IHC dilution:1: 20-100

Datasheet PDF