GFI1 Antibody

Catalog Number:

47575

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q99684
NCBI Gene ID:2672
Gene Accssion:NP_005254

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human GFI1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total GFI1 protein.

Applications:

IHC

Background:

This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.?

References:

appl_detail:

IHC dilution:1: 50-300

Datasheet PDF