GALR2 Antibody

Catalog Number:

47568

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:O43603
NCBI Gene ID:8811
Gene Accssion:NP_003848

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human GALR2

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total GALR2 protein.

Applications:

IHC

Background:

Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.

References:

appl_detail:

IHC dilution:1: 50-300

Datasheet PDF