KDM2A Antibody

Catalog Number:

47546

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9Y2K7
NCBI Gene ID:22992
Gene Accssion:NP_036440

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human KDM2A

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total KDM2A protein.

Applications:

IHC

Background:

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.

References:

appl_detail:

IHC dilution:1: 50-300

Datasheet PDF