DPPA4 Antibody

Catalog Number:

47509

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q7L190
NCBI Gene ID:55211
Gene Accssion:NP_060659

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human DPPA4

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total DPPA4 protein.

Applications:

WB, IHC

Background:

This gene encodes a nuclear factor that is involved in the maintenance of pluripotency in stem cells and essential for embryogenesis. The encoded protein has a scaffold-attachment factor A/B, acinus and PIAS (SAP) domain that binds DNA and is thought to modify chromatin. Mice with a homozygous knockout of the orthologous gene die during late embryonic development or within hours after birth. Knockout embryos are normal in size at embryonic day 18.5 but exhibit skeletal and lung tissue abnormalities. This gene, when mutated, is highly expressed in embryonal carcinomas, pluripotent germ cell tumors, and other cancers and is thought to play an important role in tumor progression. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.

References:

appl_detail:

WB dilution:1:200-1000
IHC dilution:1: 40-200

Datasheet PDF