CREBZF Antibody

Catalog Number:

47481

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9NS37
NCBI Gene ID:58487
Gene Accssion:NP_001034707

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human CREBZF

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total CREBZF protein.

Applications:

WB, IHC

Background:

Host cell factor (HCF) is a cellular cofactor required for the activation of VP16 which expresses the herpes simplex virus immediate early gene. V16 binds to HCF through a 4-amino acid motif similar to the HCF binding domain of the basic leucine-zipper proteins Luman and Zhangfei (ZF). Luman activates promoters containing cAMP or unfolded protein response elements (UPRE). Zhangfei suppresses the transcriptional activity of Luman, but requires HCF binding which may target Luman and Zhangfei to a common location. Sequence analysis predicts that the deduced 272-amino acid Zhangfei protein has a negatively charged N terminus, a leucine zipper of 6 heptad leucine repeats separated by a conserved 6-amino acid spacer, a basic domain, and a bZIP region. It is also presumed that the N-terminal acidic region of Zhangfei is an activation domain.

References:

appl_detail:

WB dilution:1:500-2000
IHC dilution:1: 25-100

Datasheet PDF