GCSH Antibody

Catalog Number:

47447

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P23434
NCBI Gene ID:2653
Gene Accssion:BC000790

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human GCSH

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total GCSH protein.

Applications:

IHC

Background:

Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome.

References:

appl_detail:

IHC dilution:1: 50-200

Datasheet PDF