SORBS2 Antibody

Catalog Number:

47424

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:O94875
NCBI Gene ID:8470
Gene Accssion:BC011883

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human SORBS2

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total SORBS2 protein.

Applications:

IHC

Background:

Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.?

References:

appl_detail:

IHC dilution:1: 150-300

Datasheet PDF