RIC8A Antibody

Catalog Number:

47407

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9NPQ8
NCBI Gene ID:60626
Gene Accssion:BC011821

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human RIC8A

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total RIC8A protein.

Applications:

IHC

Background:

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

References:

appl_detail:

IHC dilution:1: 50-300

Datasheet PDF