SF3B3 Antibody

Catalog Number:

47404

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q15393
NCBI Gene ID:23450
Gene Accssion:BC000463

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human SF3B3

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total SF3B3 protein.

Applications:

IHC

Background:

This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.

References:

appl_detail:

IHC dilution:1: 50-300

Datasheet PDF