JPT1 Antibody

Catalog Number:

47344

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9UK76
NCBI Gene ID:51155
Gene Accssion:BC001420

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human JPT1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total JPT1 protein.

Applications:

IHC

Background:

Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (PubMed:22155408).

References:

appl_detail:

IHC dilution:1: 30-150

Datasheet PDF