PNRC2 Antibody

Catalog Number:

47336

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9NPJ4
NCBI Gene ID:55629
Gene Accssion:BC001959

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human PNRC2

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total PNRC2 protein.

Applications:

IHC

Background:

Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).

References:

appl_detail:

IHC dilution:1: 50-300

Datasheet PDF