GSKIP Antibody

Catalog Number:

47335

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q9P0R6
NCBI Gene ID:51527
Gene Accssion:BC004818

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human GSKIP

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total GSKIP protein.

Applications:

IHC

Background:

This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene.

References:

appl_detail:

IHC dilution:1: 30-150

Datasheet PDF