PCSK5 Antibody

Catalog Number:

47322

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q92824
NCBI Gene ID:5125
Gene Accssion:BC012064

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human PCSK5

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total PCSK5 protein.

Applications:

IHC

Background:

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B).?

References:

appl_detail:

IHC dilution:1: 25-100

Datasheet PDF