ECD Antibody

Catalog Number:

47313

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:O95905
NCBI Gene ID:11319
Gene Accssion:BC000721

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human ECD

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total ECD protein.

Applications:

WB, IHC

Background:

Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212).

References:

appl_detail:

WB dilution:1:200-1000
IHC dilution:1: 25-100

Datasheet PDF