HLA-DQB1 Antibody

Catalog Number:

47288

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P01920
NCBI Gene ID:3119
Gene Accssion:BC012106

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human HLA-DQB1

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total HLA-DQB1 protein.

Applications:

IHC

Background:

HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants.

References:

appl_detail:

IHC dilution:1: 30-150

Datasheet PDF