HBG1/HBG2 Antibody

Catalog Number:

47276

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P69891/P69892
NCBI Gene ID:3047/3048
Gene Accssion:BC010914

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human HBG1/HBG2

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total HBG1/HBG2 protein.

Applications:

WB, IHC

Background:

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

References:

appl_detail:

WB dilution:1:500-2000
IHC dilution:1: 50-300

Datasheet PDF