LSM10 Antibody

Catalog Number:

47271

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q969L4
NCBI Gene ID:84967
Gene Accssion:BC007623

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human LSM10

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total LSM10 protein.

Applications:

IHC

Background:

LSm10 (U7 snRNA-associated Sm-like protein LSm10) is a nuclear protein that belongs to the snRNP (small nuclear ribonucleoproteins) Sm protein family. The survival of motor neurons (SMN) complex mediates the assembly of snRNPs involved in splicing and histone RNA processing. A crucial step in this process is the binding of Sm proteins onto the SMN protein. LSm10 and LSm11, mammalian homologs of the yeast Sm proteins D1 and D2, are important for U7 snRNP function and subcellular localization. U7 snRNP is an RNA molecule involved in the splicing of animal histone pre-mRNAs. Lsm10 and Lsm11 also associate with pICln (Chloride ion current inducer protein), which interacts with Sm proteins to inhibit their assembly on U RNA. LSm10 interactions with U7 snRNA and pICln may provide the means for using modified U7 snRNA derivatives to alter specific pre-mRNA splicing events, potentially leading to advances in antisense gene therapy.

References:

appl_detail:

IHC dilution:1: 50-300

Datasheet PDF