MGP Antibody

Catalog Number:

47268

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P08493
NCBI Gene ID:4256
Gene Accssion:BC005272

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human MGP

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total MGP protein.

Applications:

IHC

Background:

This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia.?

References:

appl_detail:

IHC dilution:1: 50-300

Datasheet PDF