C9orf116 Antibody

Catalog Number:

47264

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q5BN46
NCBI Gene ID:138162
Gene Accssion:BC021261

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human C9orf116

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total C9orf116 protein.

Applications:

IHC

Background:

C9orf116, also known as PIERCE1. PIERCE1 is an important p53 target gene contributing to normal DNA damage response and may play crucial roles in maintaining genomic integrity against genotoxic stresses, including UVC irradiation. PIERCE1 exists as two alternatively spliced isoforms and is predominantly expressed in human small cell lung cancer. PIERCE1 knockdown induces down-regulation of proapoptotic genes including Ei24, Apaf1 and PTEN, suggesting that PIERCE1 is a proapoptotic gene. It is helpful for in-depth understanding of p53 pathways and the design of new cancer therapies.

References:

appl_detail:

IHC dilution:1: 25-100

Datasheet PDF