TIMM8A Antibody

Catalog Number:

47262

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:O60220
NCBI Gene ID:1678
Gene Accssion:BC006994

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human TIMM8A

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total TIMM8A protein.

Applications:

IHC

Background:

This translocase is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in this gene also cause Jensen syndrome; an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. This protein, along with TIMM13, forms a 70 kDa heterohexamer. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

References:

appl_detail:

IHC dilution:1: 50-300

Datasheet PDF