VDR Antibody

Catalog Number:

47234

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P11473
NCBI Gene ID:7421
Gene Accssion:BC060832

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human VDR

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total VDR protein.

Applications:

IHC

Background:

This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.

References:

appl_detail:

Immunofluorescence:1: 20-100

Datasheet PDF