SPATA19 Antibody

Catalog Number:

47212

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q7Z5L4
NCBI Gene ID:219938
Gene Accssion:BC058039

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human SPATA19

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total SPATA19 protein.

Applications:

IHC

Background:

SPATA19(spermatogenesis associated 19), also known as spergen1 (spermatogenic cell-specific gene 1 protein), CT132 or SPAS1, is a 167 amino acid mitochondrial outer membrane protein suggested to function in spermiogenesis. Expressed specifically in testis, SPATA19 is encoded by a gene that maps to human chromosome 11, which comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxiatelangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes.

References:

appl_detail:

Immunofluorescence:1: 25-100

Datasheet PDF