SLFN5 Antibody

Catalog Number:

47209

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q08AF3
NCBI Gene ID:162394
Gene Accssion:BC021238

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human SLFN5

Purification:

Antigen affinity purification

Specificity/Sensitivity:

The antibody detects endogenous levels of total SLFN5 protein.

Applications:

IHC

Background:

Slfn5 (schlafen family member 5) is an 891 amino acid protein that exists as multiple alternatively spliced isoforms and is thought to play a role in hematopoeitic cell differentiation. The gene encoding Slfn5 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

References:

appl_detail:

Immunofluorescence:1: 25-100

Datasheet PDF